“Citrate Chemistry and Biology for Biomaterials Design and Applications”


Leveraging the multifunctional nature of citrate in chemistry and inspired by its important biological roles in human tissues, a class of highly versatile and functional citrate-based biomaterials (CBBs) has been developed. Citric acid, historically known as an intermediate in the Krebs cycle, is a multifunctional, nontoxic, readily available, and inexpensive cornerstone monomer used in the design of citrate-based biomaterials. In addition to the convenient citrate chemistry for the syntheses of a number of versatile polymers that may be elastomeric or mechanically strong and tough, injectable and photocrosslinkable, and/or tissue adhesive, citric acid also presents inherent anti-bacterial, anti-clotting, angiogenic characteristics and modulates cellular energy levels leading to facilitated stem cell differentiation, which make citrate biomaterials ideal for a number of medical applications. Herein, a methodology for the design of multifunctional citrate biomaterials and their applications in regenerative engineering will be discussed.


Date(s) - Mar 02, 2018
11:00 am - 12:00 pm


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