CBE Seminar: Irene Chen

“Molecular evolution at the origin of life and applications for the present day”

Creating a living system from minimal starting materials is an important synthetic goal. A simple living system could be based on RNA molecules, which can both carry genetic information and catalyze chemical reactions. We study the emergence and evolution of catalytic RNA by mapping “fitness landscapes”, or the complete sequence-activity relationship, to gain a quantitative understanding of evolutionary potential. We also study membranes, an essential component of living systems, and their effect on encapsulated RNAs. In addition to de novo evolution of new functional molecules, we take advantage of billions of years of evolution to engineer nanomaterials based on bacterial viruses. I will present our recent results and their implications for understanding the origin of life as well as potential biotechnological applications.

Irene Chen Flyer

Date/Time:
Date(s) - Jan 11, 2019
10:00 am - 11:00 am

Location:
Boelter Hall 3400
420 Westwood Plaza Los Angeles CA 90095